Dimethyl Sulfoxide
Apexbio Technology LLC Argatroban 74863-84-6 10mM (in 1mL DMSO)
Argatroban is a synthetic small-molecule inhibitor acting as a direct binder to thrombin s active site thereby blocking the thrombin-mediated conversion of fibrinogen into fibrin It competitively inhibits thrombin-induced platelet activation and blood clot formation exhibiting an inhibitory constant (Ki) of approximately 19 nM Due to its specificity and direct mechanism Argatroban is frequently employed in experimental research scenarios to investigate thrombin-dependent coagulation pathways platelet aggregation studies and antithrombotic effects in various in vitro assays and animal thrombosis models
Cayman Chemical QuetIapIn SulfoxIde 10mg
An inactive metabolite of quetiapine; formed from quetiapine via CYP3A
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide Reagent
Dimethyl sulfoxide is an amphipathic molecule soluble in both aqueous and organic solvents. It is commonly used as an aprotic solvent and also as a reagent in organic synthesis.
Apexbio Technology LLC Mupirocin 12650-69-0 10mM (in 1mL DMSO)
Mupirocin is an antibiotic targeting bacterial protein synthesis by inhibition of isoleucyl-tRNA synthetase Structurally analogous to isoleucine it binds the enzyme s active site blocking formation of isoleucyl-tRNA thus arresting bacterial protein production with reported MIC values around 0 05 g/ml for Staphylococcus aureus Primarily active against Gram-positive strains notably methicillin-resistant Staphylococcus aureus (MRSA) it is widely applied in biomedical research focused on antimicrobial resistance soft tissue infections biofilm studies and nasal colonization control strategies
Medchemexpress LLC Jq1 1Mm Dmso Reconstitution | HY-13030-10MM DMSO RECONS
Jq1 1Mm Dmso Reconstitution
Medchemexpress LLC Arachidonic Acid-10Mm-1Ml Dmso | HY-109590-10MM-1ML DMSO
Arachidonic Acid-10Mm-1Ml Dmso
Apexbio Technology LLC Polydatin 27208-80-6 10mM (in 1mL DMSO)
Polydatin (CAS 27208-80-6) is a naturally occurring stilbenoid isolated primarily from the roots of Polygonum cuspidatum Structurally it represents the glucoside derivative of resveratrol exerting antioxidant and anti-inflammatory effects through modulation of oxidative stress-related pathways Research indicates that polydatin influences signaling cascades such as NF- B MAPK and Nrf2 contributing to its protective roles in cellular injury models including cardiovascular dysfunction neurodegeneration and inflammatory conditions Polydatin is soluble in methanol ethanol and acetone and stability is maintained by storage under sealed cool dry conditions
Apexbio Technology LLC Maraviroc(Synonyms: Selzentry, Celsentri, UK-427857, MVC), 10mM (in 1mL DMSO), CAS: 376348-65-1.
Maraviroc (CAS 376348-65-1) is a potent selective antagonist of the chemokine receptor CCR5 CCR5 functions as a coreceptor expressed on immune cells and facilitates entry of certain HIV-1 virus strains (R5-tropic) By binding CCR5 maraviroc effectively blocks HIV-1 envelope protein gp120 anchoring and consequently prevents viral fusion and subsequent cell entry In cellular assays with CCR5-tropic HIV-1 maraviroc demonstrates substantial antiviral activity (IC50 approximately 2 0 nM) and efficiently inhibits gp120-CCR5 interaction Maraviroc serves as a valuable research tool to explore CCR5-mediated viral entry and HIV tropism dynamics
Apexbio Technology LLC MLN2238(Synonyms: Ixazomib, MLN-2238, Ninlaro, MLN9708, Ixazomib citrate), 10mM (in 1mL DMSO), CAS: 1072833-77-2.
MLN2238 (CAS number 1072833-77-2) is a dipeptidyl boronic acid derivative designed as a reversible inhibitor of the 5 subunit (chymotrypsin-like activity) of the 20S proteasome with reported IC50 and Ki values of 3 4 nM and 0 93 nM respectively At higher concentrations MLN2238 also targets the proteasome s 1 (caspase-like) and 2 (trypsin-like) subunits In preclinical studies using xenograft and genetically-engineered models of hematologic malignancies MLN2238 exhibited potent antitumor activity promoting apoptosis and suppressing pathways such as NF- B MLN2238 has research applications in oncology particularly against multiple myeloma and lymphoma including in bortezomib-resistant cell lines
Apexbio Technology LLC GSK2126458(Synonyms: Omipalisib, GSK-2126458, GSK 2126458, Omipalisib (GSK2126458)), 10mM (in 1mL DMSO), CAS: 1086062-66-9.
GSK2126458 (CAS 1086062-66-9) is a small molecule inhibitor targeting PI3K and mTOR pivotal regulators in cell growth proliferation and tumor progression GSK2126458 demonstrates potent inhibitory activity against PI3K (Ki 19 pM) In colon cancer cells combined use with DDR1-IN-1 enhances its antiproliferative effects Additionally the compound induces G1 phase arrest in BT474 breast cancer cells and sensitizes nasopharyngeal carcinoma (NPC) cell lines to radiation therapy In vivo studies show that combining GSK2126458 with radiation or with MEK and BRAF inhibitors suppresses tumor growth GSK2126458 also influences cellular autophagy pathways highlighting its utility in oncology-focused biomedical research
Apexbio Technology LLC Betaxolol HCl 63659-19-8 10mM (in 1mL DMSO)
Betaxolol HCl (CAS 63659-19-8) is a selective inhibitor targeting the adrenergic receptor It demonstrates antagonist activity by competitively binding and inhibiting this receptor subtype which plays a significant role in cardiovascular regulation Betaxolol exhibits an IC value of approximately 6 M indicative of moderate inhibitory potency In biomedical research betaxolol serves as a pharmacological tool to investigate receptor signaling pathways and their involvement in conditions such as hypertension arrhythmias and cardiovascular disorders
Apexbio Technology LLC Roflumilast 162401-32-3 10mM (in 1mL DMSO)
Roflumilast is an orally available selective inhibitor of phosphodiesterase-4 (PDE-4) with an IC50 value of approximately 0 11 nM PDE-4 enzymes catalyze the hydrolysis of cyclic adenosine monophosphate (cAMP) and are predominantly expressed in various inflammatory and immune cells By selectively inhibiting PDE-4 activity Roflumilast elevates intracellular cAMP levels thus regulating cellular inflammatory signaling pathways This mechanism supports its use in the reduction of inflammatory responses associated with chronic obstructive pulmonary disease (COPD) Additionally Roflumilast has been investigated experimentally regarding its potential influence on glucose metabolism in early-stage type 2 diabetes mellitus
Apexbio Technology LLC Lomustine 13010-47-4 10mM (in 1mL DMSO)
Lomustine (CAS 13010-47-4) is an anticancer small molecule belonging to the nitrosourea class of alkylating agents It exerts its antitumor effects primarily by forming DNA cross-links leading to impaired replication and selective cytotoxicity in rapidly dividing tumor cells Lomustine shows inhibitory activity against various cancer cell lines including breast cancer (ZR-75-1 IC50 25 M) astrocytoma (U87MG IC50 8 8 M) and colon carcinoma (LS174T IC50 13 M) Due to its lipophilic nature lomustine efficiently crosses the blood-brain barrier facilitating its use in research involving central nervous system malignancies and related leukemia models
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML