Dimethyl Sulfoxide
Apexbio Technology LLC EPZ5676 1380288-87-8 10mM (in 1mL DMSO)
EPZ5676 (CAS 1380288-87-8) is a selective inhibitor targeting DOT1L a histone methyltransferase responsible for H3K79 methylation Structural studies indicate EPZ5676 occupies the enzyme s S-adenosylmethionine (SAM) binding pocket inducing conformational changes and partial opening beyond the SAM hydrophobic pocket EPZ5676 displays potent inhibitory activity against DOT1L (IC50 0 8 nM) with markedly lower affinity for other methyltransferases In MLL-rearranged leukemia models EPZ5676 reduces H3K79 methylation inhibits MLL fusion target gene expression and induces cytotoxicity in leukemia cell lines harboring MLL translocations
Apexbio Technology LLC XL-888 1149705-71-4 10mM (in 1mL DMSO)
XL-888 (CAS 1149705-71-4) is an orally bioavailable small molecule inhibitor targeting heat shock protein 90 (HSP90) It selectively inhibits HSP90 and HSP90 with IC50 values of 22 nM and 44 nM respectively while exhibiting markedly weaker inhibition against a panel of other kinases Structural analyses indicated XL-888 binds HSP90 via hydrogen bonding interactions involving the Asp93 residue In tumor cell assays XL-888 potently suppresses proliferation with IC50 values in the range of 0 1-45 5 nM XL-888 is used in oncology research particularly for studying resistance mechanisms to targeted therapies
Apexbio Technology LLC Argatroban 74863-84-6 10mM (in 1mL DMSO)
Argatroban is a synthetic small-molecule inhibitor acting as a direct binder to thrombin s active site thereby blocking the thrombin-mediated conversion of fibrinogen into fibrin It competitively inhibits thrombin-induced platelet activation and blood clot formation exhibiting an inhibitory constant (Ki) of approximately 19 nM Due to its specificity and direct mechanism Argatroban is frequently employed in experimental research scenarios to investigate thrombin-dependent coagulation pathways platelet aggregation studies and antithrombotic effects in various in vitro assays and animal thrombosis models
Apexbio Technology LLC SKI II 312636-16-1 10mM (in 1mL DMSO)
SKI II (CAS 312636-16-1) is a small-molecule inhibitor of sphingosine kinase (SK) an enzyme involved in converting sphingosine into sphingosine-1-phosphate (S1P) SKI II inhibits SK activity with an IC50 of 0 5 M through a mechanism independent of competition at the ATP-binding site Selectivity assessments showed no inhibitory effect against human kinases ERK2 PKC-I or PI3K Cellular assays demonstrate that SKI II effectively inhibits endogenous SK reducing S1P synthesis and subsequently suppressing proliferation and inducing apoptosis in various cancer cell lines including MDA-MB-231 T-24 MCF-7 and MCF-7/VP cells
Apexbio Technology LLC TMP269 1314890-29-3 10mM (in 1mL DMSO)
TMP269 (CAS 1314890-29-3) is a selective inhibitor of class IIa histone deacetylases (HDACs) specifically targeting HDAC isoforms 4 5 7 and 9 with IC50 values of 126 80 36 and 9 nM respectively HDACs catalyze removal of acetyl groups from histone lysine residues thereby condensing chromatin and repressing transcription TMP269 induces moderate cytotoxicity (IC50 22-38 M) in multiple myeloma cell lines correlating with cleavage of caspase-3 -8 -9 and PARP and enhances ER stress-induced apoptosis signaling pathways Additionally TMP269 inhibits PKD1-mediated proliferation in intestinal epithelial IEC-18 cells
Apexbio Technology LLC PF-04217903(Synonyms: PF04217903, PF 04217903, PF-4217903, PF4217903, MET inhibitor PF-04217903), 10mM (in 1mL DMSO), CAS: 956905-27-4.
PF-04217903 (CAS 956905-27-4) is a selective ATP-competitive inhibitor targeting the receptor tyrosine kinase c-Met with a reported Ki value of 4 8 nM Aberrant activation or amplification of c-Met signaling contributes significantly to tumor cell proliferation angiogenesis and metastasis PF-04217903 exhibits high selectivity for c-Met over numerous other kinases and inhibits various c-Met mutants including R988C V1092I H1094R and T1010I In cellular studies using lines such as GTL-16 and H1993 PF-04217903 inhibits proliferation and induces apoptosis In vivo it effectively reduces c-Met phosphorylation and tumor growth suggesting potential as a research tool for investigating c-Met-related oncogenic pathways
Apexbio Technology LLC TIC10 41276-02-2 10mM (in 1mL DMSO)
TIC10 (TRAIL-inducing compound 10) is a small molecule inhibitor with oral bioavailability capable of penetrating the blood-brain barrier It functions primarily by simultaneously inhibiting Akt and ERK pathways resulting in Foxo3a nuclear translocation and transcriptional activation of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) TRAIL is involved in apoptosis induction in cancer cells often compromised during tumor progression TIC10 triggers the expression of TRAIL independently of p53 status enabling apoptosis in diverse cancer cell types In preclinical xenograft models and orthotopic glioblastoma studies TIC10 has demonstrated TRAIL-mediated antitumor activity supporting its use in cancer biology research and therapeutic investigations
Cayman Chemical QuetIapIn SulfoxIde 10mg
An inactive metabolite of quetiapine; formed from quetiapine via CYP3A
Apexbio Technology LLC Mupirocin 12650-69-0 10mM (in 1mL DMSO)
Mupirocin is an antibiotic targeting bacterial protein synthesis by inhibition of isoleucyl-tRNA synthetase Structurally analogous to isoleucine it binds the enzyme s active site blocking formation of isoleucyl-tRNA thus arresting bacterial protein production with reported MIC values around 0 05 g/ml for Staphylococcus aureus Primarily active against Gram-positive strains notably methicillin-resistant Staphylococcus aureus (MRSA) it is widely applied in biomedical research focused on antimicrobial resistance soft tissue infections biofilm studies and nasal colonization control strategies
Medchemexpress LLC Arachidonic Acid-10Mm-1Ml Dmso | HY-109590-10MM-1ML DMSO
Arachidonic Acid-10Mm-1Ml Dmso
Apexbio Technology LLC Polydatin 27208-80-6 10mM (in 1mL DMSO)
Polydatin (CAS 27208-80-6) is a naturally occurring stilbenoid isolated primarily from the roots of Polygonum cuspidatum Structurally it represents the glucoside derivative of resveratrol exerting antioxidant and anti-inflammatory effects through modulation of oxidative stress-related pathways Research indicates that polydatin influences signaling cascades such as NF- B MAPK and Nrf2 contributing to its protective roles in cellular injury models including cardiovascular dysfunction neurodegeneration and inflammatory conditions Polydatin is soluble in methanol ethanol and acetone and stability is maintained by storage under sealed cool dry conditions
Apexbio Technology LLC Maraviroc(Synonyms: Selzentry, Celsentri, UK-427857, MVC), 10mM (in 1mL DMSO), CAS: 376348-65-1.
Maraviroc (CAS 376348-65-1) is a potent selective antagonist of the chemokine receptor CCR5 CCR5 functions as a coreceptor expressed on immune cells and facilitates entry of certain HIV-1 virus strains (R5-tropic) By binding CCR5 maraviroc effectively blocks HIV-1 envelope protein gp120 anchoring and consequently prevents viral fusion and subsequent cell entry In cellular assays with CCR5-tropic HIV-1 maraviroc demonstrates substantial antiviral activity (IC50 approximately 2 0 nM) and efficiently inhibits gp120-CCR5 interaction Maraviroc serves as a valuable research tool to explore CCR5-mediated viral entry and HIV tropism dynamics
Apexbio Technology LLC MLN2238(Synonyms: Ixazomib, MLN-2238, Ninlaro, MLN9708, Ixazomib citrate), 10mM (in 1mL DMSO), CAS: 1072833-77-2.
MLN2238 (CAS number 1072833-77-2) is a dipeptidyl boronic acid derivative designed as a reversible inhibitor of the 5 subunit (chymotrypsin-like activity) of the 20S proteasome with reported IC50 and Ki values of 3 4 nM and 0 93 nM respectively At higher concentrations MLN2238 also targets the proteasome s 1 (caspase-like) and 2 (trypsin-like) subunits In preclinical studies using xenograft and genetically-engineered models of hematologic malignancies MLN2238 exhibited potent antitumor activity promoting apoptosis and suppressing pathways such as NF- B MLN2238 has research applications in oncology particularly against multiple myeloma and lymphoma including in bortezomib-resistant cell lines
Apexbio Technology LLC GSK2126458(Synonyms: Omipalisib, GSK-2126458, GSK 2126458, Omipalisib (GSK2126458)), 10mM (in 1mL DMSO), CAS: 1086062-66-9.
GSK2126458 (CAS 1086062-66-9) is a small molecule inhibitor targeting PI3K and mTOR pivotal regulators in cell growth proliferation and tumor progression GSK2126458 demonstrates potent inhibitory activity against PI3K (Ki 19 pM) In colon cancer cells combined use with DDR1-IN-1 enhances its antiproliferative effects Additionally the compound induces G1 phase arrest in BT474 breast cancer cells and sensitizes nasopharyngeal carcinoma (NPC) cell lines to radiation therapy In vivo studies show that combining GSK2126458 with radiation or with MEK and BRAF inhibitors suppresses tumor growth GSK2126458 also influences cellular autophagy pathways highlighting its utility in oncology-focused biomedical research
Apexbio Technology LLC Betaxolol HCl 63659-19-8 10mM (in 1mL DMSO)
Betaxolol HCl (CAS 63659-19-8) is a selective inhibitor targeting the adrenergic receptor It demonstrates antagonist activity by competitively binding and inhibiting this receptor subtype which plays a significant role in cardiovascular regulation Betaxolol exhibits an IC value of approximately 6 M indicative of moderate inhibitory potency In biomedical research betaxolol serves as a pharmacological tool to investigate receptor signaling pathways and their involvement in conditions such as hypertension arrhythmias and cardiovascular disorders