Dimethyl Sulfoxide
Apexbio Technology LLC SL-327 305350-87-2 10mM (in 1mL DMSO)
SL-327 (CAS 305350-87-2) is a selective inhibitor targeting MEK1 and MEK2 kinases exhibiting IC50 values of 0 18 M and 0 22 M respectively MEK1/2 mediate the phosphorylation and activation of extracellular signal-regulated kinases (ERK) crucial components of the MAPK/ERK signaling pathway SL-327 treatment lowers phosphorylated ERK levels and subsequent activation of transcription factors including CREB Elk-1 and c-Fos influencing gene expression linked to synaptic plasticity In animal models SL-327 modulates drug-induced behaviors and neuronal plasticity processes making it a relevant molecular tool to investigate MAPK/ERK signaling pathways in neuroscience research
Supply Solutions Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100ml
Dimethyl sulfoxide | Purity: ?99.7%% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 100ml
Apexbio Technology LLC Ramelteon(Synonyms: Rozerem, TAK-375, Ramelteon, Melatonin receptor agonist, MT1/MT2 agonist), 10mM (in 1mL DMSO), CAS: 196597-26-9.
Ramelteon (CAS 196597-26-9) is a potent orally active agonist selective for MT1 and MT2 melatonin receptors Structurally characterized by its S-enantiomer and ether functional group ramelteon exhibits high binding affinity toward MT1 and MT2 receptors with reported Ki values of 14 pM and 112 pM respectively whereas affinity for the MT3 receptor is considerably lower (Ki 2650 nM) By activating MT1 and MT2 receptors ramelteon suppresses cAMP production in human cells expressing these receptors with IC50 values of 21 2 pM/L (MT1) and 53 4 pM/L (MT2) Given its receptor selectivity and minimal side-effect profile ramelteon is frequently utilized in research investigating circadian rhythms and sleep disorders
Apexbio Technology LLC E-64-c(Synonyms: E-64c, Epoxysuccinyl peptide derivative E-64-c, trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane), 10mM (in 1mL DMSO), CAS: 76684-89-4.
E-64-c (CAS 76684-89-4) also referred to as Ep-475 is an analog of E-64 and functions as a cysteine protease inhibitor It inhibits mammalian cysteine proteases notably cathepsins B H and L by covalently binding to their active site sulfhydryl groups Compared to E-64 E-64-c exhibits significantly higher inhibitory potency for cathepsins B and L with inactivation rate constants of 2 98 10 5 M -1s -1 and 2 06 10 5 M -1s -1 respectively Research applications demonstrated that E-64-c reduces cysteine protease-mediated protein degradation including reducing muscle proteolysis in burned rats and ischemic cerebral protein breakdown in rodent stroke models
Apexbio Technology LLC Tirapazamine(Synonyms: SR-4233, WIN 59075, Tirazone, TPZ, 3-Amino-1,2,4-benzotriazine 1,4-dioxide), 10mM (in 1mL DMSO), CAS: 27314-97-2.
Tirapazamine (CAS 27314-97-2) also known as SR259075 Win59075 or SR4233 is an investigational anticancer agent selectively activated under hypoxic conditions characteristic of solid tumors The compound is bioreduced in hypoxic tumor microenvironments to cytotoxic free radicals leading to cellular damage Tirapazamine downregulates hypoxia-inducible factor-1 (HIF-1 ) thereby influencing pathways associated with tumor adaptive mechanisms to hypoxia Combined treatment with tirapazamine and topoisomerase I inhibitors (such as SN-38 the active metabolite of irinotecan) enhances apoptosis via mitochondria-mediated caspase activation and weakened DNA repair signaling Preclinical investigations including hepatocellular carcinoma xenografts confirm this enhanced tumor suppression Clinical trials evaluating tirapazamine s anticancer efficacy are ongoing
Apexbio Technology LLC BI6727 (Volasertib)(Synonyms: Volasertib, BI-6727, BI 6727, Plk inhibitor BI6727, Polo-like kinase inhibitor BI6727), 10mM (in 1mL DMSO), CAS: 755038-65-4.
BI6727 (Volasertib CAS 755038-65-4) is a selective inhibitor of Polo-like kinases (Plk) primarily targeting Plk1 with an IC50 of 0 87 nM and showing lower potency towards Plk2 (IC50 5 nM) and Plk3 (IC50 56 nM) Plk1 regulates the G2/M cell cycle transition and is commonly overexpressed in various tumor types representing a potential therapeutic target BI6727 inhibits proliferation across multiple tumor cell lines including colorectal (HCT116 EC50 23 nM) lung (NCI-H460 EC50 21 nM) melanoma (BRO EC50 11 nM) and hematologic cancer (GRANTA EC50 15 nM) In vivo BI6727 administration induced apoptosis and reduced tumor growth in mouse HCT116 and NCI-H460 xenograft models
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 g/mol | C5H9NO5S | 10 MG
Carbocysteine sulfoxide is a small-molecule impurity of carbocisteine intended for research use. The substance is identified by CAS number 5439-87-2, has the molecular formula C5H9NO5S, and a molecular weight of 195.19 g/mol. It is provided in small-mass packages for laboratory and analytical applications.
- Used as an impurity reference for analytical method development.
- Supplied in small-mass packages suitable for laboratory research.
- Identified by CAS number 5439-87-2 for substance tracking.
- Molecular formula C5H9NO5S and molecular weight 195.19 g/mol.
- Intended for research use only; not for human or clinical use.
Apexbio Technology LLC ML-323(Synonyms: ML323, ML 323, USP1 inhibitor ML323, ML-323 USP1-UAF1 inhibitor, USP1/UAF1 inhibitor ML323), 10mM (in 1mL DMSO), CAS: 1572414-83-5.
ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex with a reported IC50 of 76 nM USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2 In cellular assays ML-323 inhibits USP1 UAF1-mediated deubiquitination enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families providing a valuable research tool for DNA repair and cancer biology studies
Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)
Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics
Medchemexpress LLC Ru.521 10Mm Dmso Solid 1Nl | HY-114180-10MM DMSO SOLID
Ru.521 10Mm Dmso Solid 1Nl
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 200L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 200L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology, 67-68-5, MFCD00002089, 250mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, for molecular biology, Synonym: DMSO
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC TAK-242 243984-11-4 10mM (in 1mL DMSO)
TAK-242 (CAS 243984-11-4) also known as resatorvid is a cyclohexene derivative that functions as a selective inhibitor of Toll-like receptor 4 (TLR4) signaling Mechanistically TAK-242 binds specifically to the intracellular domain of TLR4 disrupting its interaction with downstream adaptor proteins and thus suppressing activation of inflammatory signal pathways triggered by lipopolysaccharide (LPS) In vitro TAK-242 inhibits LPS-induced production of nitric oxide TNF- and interleukin-6 in macrophages (IC50 1 1 11 nM) Preclinical animal models indicate its potential usefulness in mitigating inflammatory responses associated with neuropsychiatric conditions triggered by stress